The End of Alzheimer’s

Alzheimer’s will kill about 45 million of the currently living Americans. 45 MILLION. It’s in the top five leading causes of death. While that’s difficult to wrap your head around, all hope is not lost. More research concerning this disease is surfacing all the time. Our understanding of it and ways to combat it continue to increase.

Our guest today is one of the heroes leading the charge against Alzheimer’s, Dr. Dale Bredesen. He’s recognized that traditional means of treating Alzheimer’s aren’t very effective. Armed with his knowledge as a medical doctor, his career has been guided by a simple idea: that Alzheimer’s as we know it is not just preventable, but reversible. That’s exactly what we talk about today.


Meet Dr. Bredesen:

An internationally recognized expert in the mechanisms of neurodegenerative diseases, Dr. Dale Bredesen’s career has been guided by a simple idea: that Alzheimer’s as we know it is not just preventable, but reversible. Dr. Bredesen’s dedicated pursuit of the science that makes this a reality has placed him at the vanguard of neurological research and led to the discoveries that today underlie the ReCODE Protocol™.

Dr. Bredesen earned his M.D. from Duke University Medical Center and served as Chief Resident in Neurology at the University of California, San Francisco (UCSF), before joining Nobel laureate Stanley Prusiner’s laboratory at UCSF as an NIH Postdoctoral Fellow. He held faculty positions at UCSF, UCLA, and the University of California, San Diego. Dr. Bredesen also directed the Program on Aging at the Burnham Institute before joining the Buck Institute in 1998 as founding President and CEO.

Dr. Bredesen’s research explores previously uncharted territory in explaining the physical mechanism behind the erosion of memory seen in Alzheimer’s disease, and has opened the door to new approaches to treatment. This work has led to the identification of several new therapeutic processes that are showing remarkable early results. Dr. Bredesen is a prodigious innovator in medicine, with over thirty patents to his name. Notably, he put much of his findings and research into the 2017 New York Times‘ Best-Seller, The End of Alzheimer’s.

His most recent book, The First Survivors of Alzheimer’s, presents the stories of seven individuals who reversed their cognitive decline using the ReCODE Protocol

Dr. Dale Bredesen 0:00
Alzheimer’s is fundamentally as we discovered a network insufficiency. In other words, what I mean by that is, you have a whole set of things, as you alluded to in your brain that are critical for making and keeping synapses making and keeping connections. Okay, and now when you have too little supply or too much demand, your brain literally has to downsize. So you have two modes, we just we looked at the molecules that are actually involved with this. And there is this master switch, which is the parent of the amyloid that everybody vilifies in this disease, we always think of Alzheimer’s, as this is a disease where your brain D generates true, and it’s due to this amyloid well actually, the amyloid is part of a response to various insults.

Brian Strickland 0:55
You’re listening to the nutrition world podcast, a show about navigating the intricacies of holistic wellness. We’re a natural health food store located in Chattanooga, Tennessee, and we believe that optimal health and peak performance should be accessible to everyone.

Ed Jones 1:18
Hello, everyone, here I am Ed Jones, again, with nutrition world and nutrition worlds podcast. You know, one of the legacies I want to leave in my life. Here I am almost 66 years old, been in this business of wellness for almost 44 years. So well over four decades. And early on. It was you know, different, probably a paradigm. But now, the last two decades, it’s about empowering people. Because we have a system that’s very broken in some ways. And there’s a lot of great people in that system who care. But the system itself seems to be broken, which inhibits a lot of us to have healing, have advice have education, that actually works. Number one and two is safe. And that’s not being talked about in any Oh, hardly a mainstream medicine. You know, I follow all of the people in the area of wellness. We have 17 practitioners at my Wellness Center. And it astounds me how much information is actually out there that is not being filtered down to the practicing healthcare worker, practicing physician practicing nurse practitioner. And there’s a lot behind that. But the gentleman today that we have has been one person I followed for many, many years. And it is so important. Today we’re going to be talking about Alzheimer’s. We all are, are known people who have it. And like Dr. Bredesen, who I’m going to announce here in a second in his book, he says we all know people who have been cured of cancer. But how many people do we know that? Has? We won’t even say the cure word managed Alzheimer’s very well, almost no one. So you know, many years some years ago, there was a book written the end of Alzheimer’s by Dr. Dale Bredesen and Dr. Bredesen is an internationally recognized expert in the mechanisms of neuro degenerative diseases, such as Alzheimer’s. He had a faculty position University of California, San Francisco, UCLA, and University of California, San Diego, and directed the program on Aging at the Burnham Institute before coming to the Buck Institute in 1988. He is not only super credible, extremely intelligent, but he’s a brave hero in my mind, and it takes brave heroes to step out of the mainstream and speak truth and welcome to nutrition world. Dr. Bredesen,

Dr. Dale Bredesen 3:35
thanks so much for having me, I’d really appreciate it.

Ed Jones 3:38
And you know, I’ve read your book, read it early on, and what my main hobby in life is studying integrative holistic methods to help empower people and myself as the aging process occurs. And we all know pretty much what Alzheimer’s remains to anyone in this world. And I think most people have a great great fear of Alzheimer’s probably more than they even do cancer and heart disease. And because one, we’re not looking at anything that seems to be making a difference other than babysitting them as they get further down the spiraling hole of despair, basically. And the one thing that I want to say early on, I know you’ll say it is there’s like if we have a house that has 36 holes in the roof, and we fix two of those, we’re really not going to do anything to prevent the damage from within in that house. Well, that’s what you say, is really there’s like 36 different components to why we have neurodegenerative diseases. So welcome again to Nutritionals podcast, Dr. Bredesen, let’s start talking and empowering people. How can they help them and their family members with this information that you have?

Dr. Dale Bredesen 4:43
Yeah, that’s a great point. So let’s start by saying let’s start by putting this in perspective. So the COVID 19 pandemic has killed over 1 million Americans now. Alzheimer’s, of the currently living Americans will kill till about 45 million of the currently living Americans. So it actually dwarfs the COVID 19 pandemic. There’s some information that it’s now become the third leading cause of death, but it’s in the it’s in the top five or so, and depends on which study, you look at whether there were autopsies etc. So it is remarkably common, unfortunately. And the main thing that we found we spent 30 years in the lab and published over 220 Peer Reviewed papers. The main thing that we found was that when you look at this disease, it is not a simple disease. What for example, like pneumococcal pneumonia, you get the pneumococcus. You treat the pneumococcus things are good, even though you might have other problems going on. We as physicians have gotten away with treating just that one thing. Alzheimer’s is fundamentally as we discovered a network insufficiency. In other words, what I mean by that is, you have a whole set of things, as you alluded to in your brain that are critical for making and keeping synapses making and keeping connections. Okay, and now when you have too little supply or too much demand, your brain literally has to downsize. So you have two modes. We just we looked at the molecules that are actually involved with this. And there is this master switch, which is the parent of the amyloid that everybody vilifies in this disease, we always think of Alzheimer’s as, oh, this is a disease where your brain regenerates true. And it’s due to this amyloid Well, actually, the amyloid is part of a response to various insults. And there are four big areas. And you mentioned like so what can we do? How do we empower people? So first of all, to know, this is more than just about amyloid. So there are four big areas. Number one, it’s anything that causes ongoing inflammation. And that can be a poor oral microbiome, that can be a leaky gut. That can be chronic sinusitis. That can be herpes simplex, any of these things that cause long term inflammation can be just a horrible diet, these things will tell your brain you got to work a little harder, you got to work extra. And so now as we get a little older, that can actually make it so that you cannot keep up with that demand. The second thing is exposure to toxins. And those are three different types of things in organics, things like mercury or air pollution, organics, things like glyphosate, tolerating benzene, and then bio toxins. That’s the big surprise related to things like mold. And if you’ve got the various types of mold that caused the bio toxins that can be damaging to your brain, and that’s really five major mold species. Stacie buttress, which is that toxic black mold, Aspergillus, Penicillium Ki, tomyam, and walima. So you should everyone should know, check it out, which is why we recommend everybody who’s 45 years of age or older, please get a Cognos copy. We all know to get a colonoscopy, when you turn 50. Don’t forget your brain, get a colonoscopy. If you’re 45 years of age or older, it’s pretty easy to do. And we can then tell you are you at high risk or things and make sure let’s make sure that everyone stays sharp to 100. So those are the first two things inflammation and toxins, then low energetics, that’s the other part. So, energetics, you’ve got to supply your brain, that’s your blood flow to the brain. That’s your oxygenation, which is why so many people with sleep apnea have cognitive decline. That’s your mitochondrial function, which is why you support your mitochondria, of course, and that’s your ketone, because your brain has to burn either glucose or ketones. And so you want to be able to go back and forth. For many of us, we’re able to go back and forth between glucose and ketones, the brains happy, as we get a little older, we lose both of those, we lose the glucose because we have insulin resistance because of poor nutrition. And on the other hand, because we have this chronically high insulin levels, because of the high carb diets, we’re not able to produce and utilize the ketones so we have the worst of both worlds. So when we see patients with cognitive decline, this is an energetic emergency. And then the last of the four is trophic influences. And that means growth factors like nerve growth factor in BDNF. BDNF goes up with exercise. So good thing for exercise. It also goes up with being in ketosis. Also goes up with things like whole coffee, fruit extract, all those things can boost your BDNF and as I mentioned, ng F and then now the second part is hormones. So estradiol testosterone, progesterone, pregnenolone, thyroid DHEA all important for brain function. And then the third of those is nutrients, things like vitamin D, vitamin B 12, omega threes, these are all critical. Choline is another big one, because it is a precursor for the acetylcholine, that is the most important neurotransmitter for memory, and which is low, by the way in patients with Alzheimer’s. So now instead of looking at this disease, and, and the risk for this as simply something simple that, oh, let’s get rid of a misfolded protein, then you start to see that it actually makes some sense. This is a beautiful, beautiful network in your brain that you are impacting. And your brain can now go into either a mode of building and maintaining when things are good, or it can go into a protective downsizing mode, which is what ultimately becomes Alzheimer’s, much as we saw with COVID-19. We were told in early 2020, that we were should shelter in place that we should socially distance we shouldn’t be going into work and what happened we entered a recession. That’s exactly what’s happening with your brain. Your brain has these insults, it says I’m moving now into a protective downsizing mode. And guess what? The amyloid that is vilified in this disease actually is an anti microbial agent, as professors Robert Moyer and Rudy tansy from Harvard showed a number of years ago. So it’s important for us to understand what’s actually going on, then we can check out and see for each person, because each person is different. What are your insults, what are the things that are creating risk for you, and then, of course, that includes your genetics, and then we can address those things. And we have tremendous results with a published trial in which 84% of people actually improve their scores didn’t just slow their decline actually improve their scores.

Ed Jones 11:56
That is mind boggling. Number one, because one is, is certainly speaking my language to is it gives people such hope. And the hope has to come from those who understand this 36 holes in the roof philosophy. And because traditional medicine is a reductionist type of medicine, where they are trying to find a single molecule to fix a single issue, that will never happen with this complex disease. And I use in my analogies when I talk to clients every single day. And then orchestra analogy that if you had an orchestra with 500, instruments and musicians, and it was out of tune, you’ll never go pick George out of the group and go fix the music. It’ll be dozens of people that you need to tune in, perhaps instruments the same, obviously with the analogy of you and 36 holes in the roof. And you mentioned mold, mold is so epidemic, and you’ll never find a traditional practitioner who will one recognize it or know a lot about it most likely, and it plus all the other things that you’re talking about. I just am so inspired by the fact that you have a system I’ll say or protocol, that an integrative physician or even a person who is very skilled or wellness skilled could actually take the recommendations from your bloodwork, which we like you say you have to see and personalize. Why is this person going down this spiraling path? Well, the only way to do that is to have a checks somewhat, and the blood testing, obviously, is the most accurate way to do that, and then set up a plan. And that plan is, is using a lot of nutrients and also lifestyle. And and and but that’s how it works. I mean, yes, it would be cool to have that single pill. That’s never going to happen. Is it Dr. Bredesen?

Dr. Dale Bredesen 13:40
Yeah, you know, it, could it it might, but it doesn’t actually fit the biology. What I actually think will happen is that these kind of silly ideas now, which are really kind of now outdated, we’re going to give you a single drug, as you said, you know, one molecule is going to cure this entire network of things, which is actually naive. Instead, let’s take a precision medicine approach, just as is being done very successfully with some cancers. Let’s look at all the different pieces. Let’s address those. And then let’s add a drug on top of the protocol that targets specific things. So for example, a mediator Tao is one of the one of the mediators of the pullback. So his amyloid fine amyloid is there, but you can’t get rid of the thing that’s actually protecting you. And just expect that that alone is going to be enough. Let’s get rid of all the things that are actually causing the problem, then we can begin slowly to get rid of the response to the problem makes a lot more sense. And the other thing I should mention, when you you mentioned the 36 holes in the roof. Well when you look at for each person, what you see is that different people have different subtypes of Alzheimer’s, we see people where it’s more of an inflammatory process. That’s the main bad actor that is causing this response. On others, it’s more of an a trophic process, you don’t have enough support others, it’s more of a toxic process. You’ve got exposure to those mycotoxins that as you said, physicians aren’t even looking for them. And unfortunately, they are very common causes of disease. When others of course, you have infections that are typically not known about and you know, there’s some really interesting work where people took cells, brain cells basically looked at, okay, if we infect these with herpes simplex, because we know that herpes simplex is associated with increased risk for Alzheimer’s. And in one remarkable study from Taiwan, just treating outbreaks of herpes simplex on the lip. And people who were in middle age, they reduced their risk for dementia quite a bit more than half striking reduction. So they said, you know, how is it that herpes which we know infects brain tissue, but when you look at with someone with Alzheimer’s, you know, you don’t see a rampaging Herpes Simplex infection. So how does this work? What they found was really interesting. They had to go to very, very small infection, literally one virus per 10,000 cells to get this Alzheimer type response. So it looks like what’s happening here is you’re getting these minimal, minimal, it’s not like a rampaging infection. Here, you’re getting these minimal exposures. And it is to the toxins and various infections. Bacteria from the mouth had been found in the brain, sa P gingival. Atlas, which is one of the ones that’s associated with poor dentition has been found in the brain of many patients with Alzheimer’s. So it’s this response where you’re saying, Okay, we are under threat. Even though the infection itself is currently minimal, we’re going to put out this response that actually walls this off the amyloid sequesters these microbes, and kills them. So you are going to have to work with a slightly smaller brain, well, instead, let’s go the other direction. Let’s get rid of these things, instead of trying to get rid of what they’re walled off with. And will we that approach has actually led to much better outcomes, as I mentioned, and our studies are freely available online. So you can look up a journal of Alzheimer’s disease, it was published, just this past June the results of our clinical trial, and we’re now starting a larger randomized controlled trial this year.

Ed Jones 17:26
How exciting. Gotta cover the era set drug, what’s your opinion on that?

Dr. Dale Bredesen 17:31
Such a good point. So as you know, there are three different types of drugs now for Alzheimer’s heiress apt and similar ones, increase your cholinergic tone. So yes, they they’re basically saying, we’re going to prevent your brain from breaking down this acetylcholine, we tend, as I say, to go on the nutritional side, and let’s give you more to begin with, instead of poisoning your enzyme that breaks it down. The problem with it is and it does give you a short term burst. But the problem with it is number one, when people who took that drug were followed over years, they actually did worse than people who were not followed, unfortunately. Second thing is, if you cold turkey that if you take it and then you suddenly stop, you get much worse because your brain responds to your inhibiting one of its natural enzymes by making more of that enzyme. So now you suddenly stop it, you’ve got more of this and now you really go downhill with the acetylcholine. So that’s, that’s the issue can be okay, for short term, not a good idea for long term, please don’t cold turkey at second group mantiene, which is basically trying to prevent this activation, so called excitotoxicity. It has such a tiny impact that the people who are on it, their families couldn’t tell who was on the placebo and who was on the drug. So it’s a tiny, tiny effect really has not helped and also, by the way, shown over the long haul, people who took it didn’t do as well. Now the one that’s gotten all the press recently, as you know, these are the anti amyloid antibodies. The idea there is let’s get rid of that amyloid and then you won’t have Alzheimer’s disease. Well, it’s turned out that’s just incorrect. And so many of these failed Bappa newsa Mab was the first it failed. It didn’t make people any better. Solon Aiza Mab ganton era mad cronyism ad these are all antibodies that have failed at a Cana Mab came out. And in one study, it failed. And in one study, it had a tiny effect. Now when I say at effect, it doesn’t make people better. It doesn’t keep them the same. What it does is it slowed the decline in early stage people only by 22%. Now, you know they hailed this as a breakthrough. If Elon Musk told you that everybody in SpaceX died because the the missiles exploded And now the big breakthrough was they died 22% Later, you wouldn’t be very impressed. I mean, that’s the problem here. It really doesn’t make you any better. So now the lat the latest one is called Le Cana Mab. And that’s just been approved on accelerated approval by the FDA. And again, does it make you better it’s, it’s slowed by 27%. Now, for comparison, what did better than the Cana Mab, extra virgin olive oil alone has also been published, it had better outcomes than Lucania Mab in terms of the studies. So this is a minimal, minimal effect. But of course, the drug company is paying many people to say this is great stuff, all the experts have been paid. They say, Oh, this is wonderful. The Alzheimer’s Association says we think this is an important drug. The bottom line is is a drug that was developed, because they didn’t understand how the disease actually works. And so the idea was, let’s just get rid of the amyloid, I actually think the time to do that is after you’ve gotten rid of all the things that are causing it, and then do it very slowly. But they’re doing it the opposite. They’re doing it just as a monotherapy. And they’re doing it with massive amounts to get rid of all the amyloid. And so you can imagine a lot of these people actually get worse. And here’s an example. One of the things that amyloid does in protecting you not only does it wall off these various organisms, but it also patches, rents in blood vessels. So it is like putting a patch on a tire. Now you’re giving a drug that rips that patch off. So what do you think’s going to happen? People bleed into their brains. And in fact, there are brain there is brain bleeding is one of the side effects of this drug. Three people so far have died in association with taking this drug. So I think we have a ways to go before we can say, you know, here’s a drug that’s really fantastic for Alzheimer’s. And so look Cana Mab is not that drug. There’s a group of physicians that have urged the FDA before giving full approval because they’ve just given accelerated approval. Now, so far, they’ve urged them to reconvene an outside objective expert panel to look at does this really help? Is it really worth the risk, etc. And, of course, the push has been the opposite. Let’s, uh, let’s go ahead, and let’s approve this immediately. And let’s pay massive, I should mention, this will increase the cost of Medicare for everyone, this will cost somewhere by the time you include the infusions because you have to go in to get this injected. By the time you you have to have scans because you’ve got to see if you’re bleeding into your brain, you’re looking at somewhere between 25 and $50,000 per year for the rest of your life. So there’s a lot of suboptimal approach here. And I think we can do much better. And as we showed in our trial, we can do much better, where we can actually improve people for much, much less expense.

Ed Jones 23:06
Amazing, and what common sense. And I always like to go back to a term I started using 20 years ago, ancient wisdom, you know, as smart as we get smart as we think we are, we still can’t fool basically Mother Nature, or God or the universe, whatever design this intricate, massive, beautiful orchestra within us, you stop one thing, and you think it’s good. Well, you end up doing like, like the Cox two inhibitor, we take a drug, you know, a painkiller? Well, it slows, it slows your pain down, but then it causes heart attacks. It is such a magical little balance that goes on within our system and the traditional people don’t really recognize it. Secondly, is we have an underlying agenda of profit to a level that has never been seen in the history of mankind, that actually doesn’t put the person first it puts the profit first. And that is not a very healthy system for this country, for sure. Or for us individuals at all. Is it

Unknown Speaker 24:02
it’s such a good point, because you know what I found I trained way back in the 1970s and 1980s and classical medicine, you you decide what it is, that’s the goal and in medicine, you know, is this measles? Is it a broken leg? What is it and then you either send the person to surgery or you write a prescription? Now 21st century medicine is not about what it’s about why, why it is why did you get Alzheimer’s? Or why are you starting to have cognitive problems. And I should mention, the approach we’ve taken also takes normal cognition and improves it because most of us have some sub optimal nature of our cognition because we’ve got some exposure to these various things. And so the idea there is to look at what’s actually causing now what we found is exactly what you said, people have made decisions, am I going with the truth? Am I going with the data what actually is for the person or am I going with with what maximizes profits for the company? Or what are a magnet and go with the politics, there is a lot of push from a lot of these various medical politicians to say, Okay, we’re gonna go with this, even though the drug doesn’t work very well, we’re going to push you to use this drug. And I think this is really unfortunate because I think people are not being served, they’re not getting the best outcomes. Because as you say, there are a huge amount at stake this, this could be any drug that actually works well for Alzheimer’s will be a $500 billion drug. So the company has actually spent around $28 billion so far, pushing this drug and so no surprise, they are paying people various things here, as as one person pointed out, virtually every op ed that has been written in support of this drug was written by someone who was on the take from the drug company. So this is this is unfortunate.

Ed Jones 25:54
Well, we have to take control of our own health, to empower ourselves. And we have to find what I used a lot of times the analogy, we have to find a team to help us age gracefully. And that team has to be a trusted team of people who kind of have their eyes open, who are a little bit braver, certainly, you’re the king of bravery. And I’d say often too, I think as we age, we have to decide are we going to go into the regular pharmacy or the green pharmacy, not meaning that all things in the natural world are totally healthy and good and great. We all have our issues. But the thing is your protocol for Alzheimer’s, I can only imagine how we’ll also escalate the health cardiovascular health, the physical health, the mental health, forget that even help the Alzheimer’s to help slow it down, prevent it from happening, sitting people back in a better place, that alone could add years to their health add years to their quality of life. So in your book, I know you have the protocol. How does a person Yes, start to do this? And I know that you know that we partnered new partners, some of his life seasons, which is amazing quality company, but they need they need help in order to make all this happen. What’s their first step?

Dr. Dale Bredesen 27:02
Absolutely, this is a really good point. And we have by the way, there is training, we call this protocol recode for reversal of cognitive decline, we’ve now trained over 2000 physicians, and as well as neuro psychologists, nurse practitioners, health coaches, brain health coaches, you know, on and on it so to look at and to understand how to do this, because as you said, you really have to look at what’s causing the problem. And so you can think about this essentially in three steps. Step one is the basics. Just what you were saying. You want to get make sure that you optimize things. And the basics are diet, exercise, sleep, stress, brain training, some detox and some targeted supplements, and yeah, supplements. You know, as a physician who never used supplements when I was first trained, of course, they can be helpful. But again, people will try to tell you it’s a cure for this or that typically they aren’t, they are helping your chemistry to get on the right track, you are optimizing your synaptic chemistry. And it’s amazing how much you can do with optimal nutrition, exercise, sleep stress. And so let’s just start for a second with the with the nutrition piece of it. I am not a nutritionist, but we’re looking at the biochemistry of what is allowing you to make and keep memories, your neuroplasticity. And what works best for your brain is a plant rich, mildly ketogenic diet, we do want it to you, we want you to be not only able to get into ketosis, but to be metabolically flexible, so you can utilize glucose, but you can also utilize ketones, you must be insulin sensitive. Insulin resistance is one of the most common risk factors for Alzheimer’s disease. And there are about 80 million Americans who are insulin resistant because of these high carb diets and high stress lifestyles that so many of us are exposed to. So that’s the critical piece. And of course, you’ve got to have, it’s got to include high fiber. So again, plant rich, the fiber is good for your detox. It’s good for your glycemic load, it’s good for your lipid profile. It’s amazing how helpful this actually is. So optimal nutrition. And then of course, you could include specific herbs in there that can actually be so helpful to your cognition. There is a tremendous amount you could do arguably, the nutrition piece is the most important piece, and it’s surprising how beneficial it is for cognition. But of course you want to add the exercise, the sleep sleep, we can spend hours talking about sleep, all the different issues. It’s great to know how much sleep you’ve gotten. What’s your oxygenation while you’re sleeping? Most people aren’t checking most doctors aren’t checking the good news. You can do a lot yourself just as you mentioned, you can do it with an Apple Watch. You can do it with an aura ring. You can do it with a Fitbit. You can do it with a simple oximeter. So you can look to see how your oxygenation is there was a beautiful study that showed just looking at the The average oxygenation while someone sleeping, the so called SPO to mean correlated beautifully with the size of various nuclei in your brain. So literally as your oxygenation is going down at night, your brain is shrinking. We want to get that up. It’s again, it’s part of the energetic support. So that’s the first piece, those seven things, we call that the basic seven, then you want to look beyond that the second tier is to look at do you have infections? Do you have toxins? Can we heal that gut? Good, let’s get looking at the things that are actually getting into your brains that organisms and things and let’s go after those, if you have recurrent herpes, easy to treat, you can treat it with things like valet cycler, Vir, you can even treat outbreaks with things like a lysine and things like that. So it’s relatively easy to do. So that’s the second tier look at the specifics. And then the third tier is the final piece is just troubleshooting. Okay, how are you doing? Has there been anything that’s been missed? Sometimes for some people, if they haven’t improved by the first six months, as it takes a few months, you have to remember when you get a diagnosis of Alzheimers, it’s been going on for 20 years. And I should mention, one of the biggest problems in this field is that we only recognize it as a disease in its end stages. And this is this is as if you say to people, you know, don’t come in until that lump on you has gone all over your body. Well wait a minute, I mean, we want to get as early as possible. So when people develop Alzheimer’s, we used to think of this as a disease of your 60s 70s 80s. No, it starts 20 years early, this is really a disease of your 30s 40s 50s. That takes a little while to have severe symptoms. So phase one, you have no symptoms, but you can already find abnormalities even in some people in their 20s and 30s. On PET scans or spinal fluid, okay, so most of us aren’t going to go and get that as a as a screen. That’s okay. But this next stage stage, so the second phase, is one that is called SCI subjective cognitive impairment. 100% of these people can be turned around, and we see it all the time. So if you’re having problems, remembering numbers, or you’re having problems, remembering names, and things just aren’t the way they used to be. The unfortunately, the medical community has said, Oh, don’t worry about it, it’s probably not Alzheimer’s. And if it is, we don’t have anything anyway. That’s not That’s the opposite of what you want to do. Get in find out why you’re not as sharp as you were, there are typically going to be reasons and again, the cog Nasca P will tell you, and you can address these things. Sometimes you’re going to have some mild insulin resistance, sometimes you’re going to have some systemic inflammation, these are things that are easily picked up and addressed. Now that last sei lasts on average, 10 years. So we have a huge window, where we can really bring people back to normal. The third stage out of four is one that is called MCI mild cognitive impairment. And I should say that’s where the ones were, that were treated with the anti amyloid antibodies. This is like, it’s unfortunate that people call it mild cognitive impairment, it’s like telling someone don’t worry, you only have mildly metastatic cancer. It’s a late stage of the process. This should really be called a relatively late stage Alzheimer’s disease, but it’s called MCI. Now in our trial, 84% of those people got better. We didn’t in a trial, we didn’t even take the ones that are Sei, those are the easy, easy ones to fix. We took the MC eyes and then early into dementia, which is very similar to the these amyloid trials, that each year, about 10% of those people will convert from MCI to dementia. And by definition, what these mean is, SCI means you know that something’s wrong, but you’re still capable of scoring in the normal range on cognitive testing, which is why your doctor will say, Oh, come back later. We had one guy recently who actually was all the way into the fourth stage. And his doctor told him, yeah, this is just normal aging. Oh my gosh, no, this guy actually had fairly significant dementia. So that’s Sei. MCI is where you now are starting to have problems with your cognitive testing as well. But you’re still able to do your activities of daily living. The fourth and final stage dementia means by definition, you started to have trouble with your activities of daily living, taking care of yourself, paying your bills, doing your normal things, driving, things like that. So that is the dementia stage. And some of those people actually can turn around as well. But it gets harder and harder and harder as you go later and later and later, which is why we urge everyone, please get in as early as possible because there’s so much that can be done.

Ed Jones 35:02
That is that is such great hope. It also I know, some people are gonna hear that and say it sounds overwhelming. Well, you know, I tried to put together a system that can empower people everywhere across the United States, you do have to search for these people who are credible, like you educated, open minded and are seekers of the truth, because it’s not going to be found in traditional medicine. Secondly, I would guess that you will agree to this insurance won’t really pay for these practitioners, because no system in this country is going to recognize the philosophy that you and I both believe in, which is more integrative which is fixing 30 or looking at 36 holes and fixing at least 15 that are not working, because it is a reductionist system. I love the fact she’s talked about the noni the oxygen level, because my aura ring has been one of the things I talk about the most in regard to sleep has been so informative to me because it actually helped me put together better plans to help me achieve better rim better, deep and better oxygen based on the fact that I can say what did I do last night? That made me so good. What I do that made me so poor, and I did a an ebook years ago is one of our most popular on nutrition If they go, someone goes here, just type in ebook sleep. And I talk about recreating the rhythm of sleep. And that is very important because you don’t have insomnia, because you lack an Ambien deficiency, you have it because multiple factors exactly like Alzheimer’s, multiple factors play into it. So we have to personalize those multiple factors, your book. So if someone wants to start this plan, first off, become educated, they just order your book, you have to write

Dr. Dale Bredesen 36:35
three. So the first one, you mentioned that you held it up there, the end of Alzheimer’s, then there’s the end of Alzheimer’s program, and then the first survivors of Alzheimer’s. And so this I was really excited about writing this first of all survivors of Alzheimer’s because so many people had gotten better and had written about their story. So I asked seven of them, would you write a more extensive story talk about what you went through talk about what your doctor said to you talk about how you started doing this talk about what was easy, and what was hard. And these are just compelling story. I challenge anyone to read these stories, and they get to give you great ideas about what to do. Without it bringing a tear to your eyes. Some of these are amazing talking about watching. One person talked about watching her mother die of Alzheimer’s watching her fight her grandmother and her father, and then starting to develop the symptoms herself looking at our children like oh my gosh, is this going to keep going through our family? And she has turned around and done very, very well. So these are these are important things. Now it’s easy, you know how to use How do you do this without getting overwhelmed? It’s easy. Number one, you can either train, go look at recode 2.0 training, or simply look up. You can go to my COG daska, or Dr., or Apollo healthcare. We partnered with Apollo health, because they are a Silicon Valley group writing software, this is the future, how do we get larger datasets and get best outcomes for everybody? So that you could go on there and you can get a trained physician and work with them. People work with health coaches also. And you could even if you’d like work with a group so that people share information, whether you know, some people like to work more with a group, some people like to do more one on one, whatever you like it’s available. And it’s it’s not overwhelming. What’s overwhelming is living in a nursing home, and having people give you drugs that are just basically meant to quiet you down and confuse you. And this is really sad to see we see it again and again and again. So yeah, please there’s there’s so much that can be done to prevent and to reverse cognitive decline. As you said, this is the first hope. We published the first examples of reversal of cognitive decline in 2014. Again, freely available online, in the journal ageing.

Ed Jones 38:59
You are again repeat for the fourth time a hero in my mind, and I think anyone who listens who has an open mind will also agree to that, you know, I have to advise people that, you know, when you ask your traditional trained people about this, they’re going to poopoo it, there’s no doubt because they’re literally don’t have a clue. They don’t know that this is the how this system works. They’re not trained into it. I mean, I fly small airplanes, I’m not trying to flying a helicopter, you put me in there, I’m gonna crash and die, because I don’t know anything about it. But there are we’re lucky to be living in 2023 at this stage because we couldn’t have access this like walking bloodwork. We do that here at nutrition where we have a lab. We couldn’t have done that 1520 years ago, you couldn’t have twisted your physician’s arm to make it happen. You write exactly what the bloodwork needs to be in your protocols. People can do that on their own. We have we have in other people and you have the whole list of professionals that can help assist putting a plan together. The thing that makes most of my clients so happy when they walk out is they’re not looking for miracles, they are looking for a plan a plan with confidence. And you give people that more than any one person living today. It because you have the experience, you have the credibility, you have the stories, and you have the science. And that is magical. I cannot thank you enough Dr. Bredesen for saving the despair of so many people in this country by the work you have done. And I know it’s not easy. So you are a blessing my friend.

Dr. Dale Bredesen 40:26
Thanks very much had we all interested if we work together, let’s reduce the global burden of dementia. You know, and with COVID and a lot of brain fog out there. Please get on active prevention or earliest reversals of cognitive decline. There is so much that can be done just as you said, All right,

Ed Jones 40:45
my friend all the best to you and your future for the next decades to keep doing this wonderful work. And again, everyone you’d get to to learn to take control of your health by putting the right people in your life that you can trust and all the best to you my friend and we will be talking again, I’m sure the next year. Thank you.

Dr. Dale Bredesen 41:02
Thanks. Take care.

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